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4-Aminopyridine in Multiple Sclerosis:Prolonged Administration Neurol 41:1344-1348, Stefoski,D.,et al, 1991 See this aricle in Pubmed Article Abstract In an earlier study,we demonstrated efficacy of single oral doses of 4- aminopyridine(4-AP)in improving motor and visual signs in multiple sclerosis(MS)patients for a mean of 4.97 hours.We attempted to determine whether efficacy could safely be prolonged using multiple daily doses over several days by administering 7.5 to 52.5 mg 4-AP to 17 temperature- sensitive MS patients in one to three daily doses at 3-to 4-hour intervals over 1 to 5 days in a double-blind study.Nine of these patients were also tested with identically appearing placebo.Thirteen of the 17 patients(76%) given 4-AP showed clinically important motor and visual improvements compared with three of nine in the placebo group.Average peak improvement scores were 0.40 for 4-AP and 0.12 for placebo.Seventy percent of the daily 4-AP improvements lasted 7 to 10 hours.The improvements for two consecutive doses of 4-AP lasted a mean of 7.07 hours(83%of the average 8. 53-hour treatment-observation period)compared with 2.36 hours for placebo (26%of the average 9.06-hour treatment-observation period).No serious side effects occurred.4-AP is a promising drug for the symptomatic treatment of MS.

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